Every year on 24 April, World Day for Animals in Laboratories serves as a stark reminder of the millions of animals used in scientific research around the globe. At present, we are faced with a critical decision: whether to perpetuate existing policies that neither incentivise the development and uptake of innovative non-animal technologies nor lead to significant reductions in the number of animals used for scientific purposes, or to implement coordinated and concrete policies and mechanisms that empower stakeholders to embrace non-animal technologies.