RIFM, Shiseido, and IIVS share the common goal of promoting the development and use of in vitro photosafety methods. Shiseido developed the photo h-CLAT, photo KeratinoSens, and photo DPRA based on the OECD-approved methods for skin sensitization (i.e., Human Cell Line Activation Test (h-CLAT, TG442E), KeratinoSens (TG442D), and Direct Peptide Reactivity Assay (DPRA, TG442C)). These assays provide data relevant to the Adverse Outcome Pathway for the identification of photoallergens. Shiseido will provide training and participate in an inter-laboratory study to support the technology transfer to IIVS using materials of interest to RIFM. 

“This project not only demonstrates our commitment to using non-animal tests, it will also streamline our ability to generate photosafety data on fragrances for the scientific community,” says Anne Marie Api, Vice President of RIFM. “We are grateful to our member company, Shiseido, for sharing their expertise with our colleagues at IIVS.”