Despite what China’s new policy might lead the public to believe, many of the worst zoonotic diseases come from domesticated animals, not wild ones. Pathogens can jump the species barrier from almost any angle. Genetic analysis suggests that the deadliest flu outbreak in history, the 1918 Spanish flu, partially evolved inside poultry farms. The 2009 H1N1 virus originated in pigs and killed up to 575,400 people during its first year. Scientists are now worried that cattle, which have long been a source of anthrax, tuberculosis, and other diseases in humans, could soon give rise to deadly flu outbreaks. Pathogenic microbes show no concern for whether or not humans have labeled an animal “wild.”