Bioprinting to help reduce animal testing in COVID-19 related research
According to published reports, Novoheart Holdings Inc., Irvine, Calif., has created a human ventricular cardiac organoid chamber, referred to as a 3D “heart-in-a-jar,” that’s used to test the effects of potential COVID-19 treatments on the heart; Prellis Biologics, San Francisco, made synthetic lymph nodes that produced virus-specific antibodies when challenged with a SARS-CoV-2 vaccine-like cocktail; and Viscient Biosciences, San Diego, is “moving quickly” to bioprint lung tissue for infectivity research, said CEO George Murphy, previously head of Organovo.
Also intent on bioprinting lung tissues using alveolar bronchial or tracheal epithelial cells is Choi-Fong Cho, assistant professor of neurosurgery at the Harvard Medical School and Brigham and Women’s Hospital, Boston. “Our most widely used model is in animals but there are many differences between a mouse respiratory system as opposed to the human anatomy,” she said. “We aim to use human lung and vasculature cells and create a functional model of the human respiratory system that can mimic and reproduce the organ’s characteristics and functions in a dish. These cells can be grown within an artificial matrix that resembles the lung’s environment to allow us to study their behavior and examine how SARS-CoV-2 affects the respiratory system.”